

This sign is reportedly absent in 12% of Horner’s syndrome

Degree of anisocoria remains relatively constant in light and dark conditions.Thought to result from a lesion in the midbrain that disables the pathway for the pupillary light reflex but does not affect the more ventral pathway mediating the near reaction.May occur after surgery (for example, to the neck) Potential causes in adults include neoplasia, demyelination and carotid artery disease.Caused by interruption of the oculosympathetic innervation at any point along the neural pathway from the hypothalamus to the orbit.Birth prevalence of 1 in 6250 for those with a congenital onset.When associated with absent or poor tendon reflexes known as Holmes-Adie syndrome.May also be seen in patients with generalised peripheral or autonomic neuropathies Sjögren’s disease and polyarteritis nodosa. Case reports of rare associations with connective tissue diseases e.g. Usually idiopathic but can occur following infection, orbital surgery or trauma affecting the ciliary ganglion.Prevalence 2 per 1,000 of the general population.Caused by parasympathetic denervation at the level of the ciliary ganglion.Depending on the level of illumination, found in up to 20% of individuals.Unequal pupil sizes in the absence of an underlying pathological cause.Although pupil anomalies are commonly benign, they may be the first or only manifestation of a serious or even life-threatening disorder.
